Selected Publications

01 Nature.png

Journal: Nature

Year: 2006

Significance: Neural stem cells operate the newly discovered Hes3 signaling pathway. Activation of this pathway leads to functional recovery in models of ischemic stroke.

02 CSH.png

Journal: Cold Spring Harbor Symposia on Quantitative Biology

Year: 2008

Significance: Activation of the the Hes3 pathway by insulin in models of Parkinson's disease promotes functional recovery.

03 PNAS.png

Journal: Proceedings of the National Academy of Sciences

Year: 2009

Significance: Activation of the the Hes3 pathway in a manner that protects unwanted effects on blood vessels in models of Parkinson's disease promotes functional recovery.

04 SciRep GBM.png

Journal: Scientific Reports

Year: 2013

Significance: The Hes3 pathway controls cultured cancer stem cells from different patients. Blocking the pathway by RNA interference (target: Hes3) kills those cells.

05 JBC.png

Journal: Journal of Biological Chemistry

Year: 2014

Significance: The Hes3 pathway protects pancreatic islet cells during injury and regulates insulin production with powerful consequences in models of type 1 diabetes.

06 Diabetes.png

Journal: Diabetes

Year: 2016

Significance: The Hes3 pathway promotes pancreatic regeneration after injury with powerful consequences in models of type 1 diabetes.

07 SciRep Xenia.png

Journal: Scientific Reports

Year: 2018

Significance: Pancreatic damage, high fat diet, and metformin administration regulate the Hes3 pathway in the brain, providing a new molecular mechanism by which metabolic dysfunction affects the brain.

Journal: FASEB J

Year: 2019

Significance: Some cells in aggressive brain cancers can evade current therapies by switching from the standard molecular mechanisms that regulate their growth and survival to an alternative one. In this way, they become resistant to therapies that target the standard molecular mechanism. Knowing this ability allowed us to define the alternative mechanism and to identify treatments that target the cells that use it. Simply put, we discovered an escape route that cancer cells use to evade therapy and then we found drugs that block it.

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